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酒不醉人人自醉

 

精簡版於20181012日晴報刊登



 

有些人會有注意力缺陷-多動障礙 Attention deficit hyperactivity disorder ADHD。他們做事三心兩意、心不在焉會過度活躍、坐立不安。小朋友出現這些症狀會被標籤為頑皮不聽話,亦影響了他們的社交和學習能力的發展。

 

ADHD 的成因很多,引起這些症候的其中一個罕有的原因是自動釀酒綜合症或稱為腸道醱酵綜合症(下稱自醸症)。這種病的患者腸道中會自動產生酒精:食用碳水化合物如澱粉和糖等,會經由腸道的微生物自動醱酵成酒精。腸道酒精的濃度可令病者去到醉酒的程度。醫學界至今有不少自釀症個案紀錄。

 

我們平常喝的酒靠肝臟中的兩個酶, 乙醇脫氫酶alcohol dehydrogenase和乙醛脫氫酶acetaldehyde dehydrogenase處理降解至不令我們中毒亦即酒醉。很多亞洲人的肝臟處理酒精的其中一個酶乙醛脫氫酶活性不足,令到量酒精也可以引起中毒,令患者醉醺醺

  

引起自釀症的主因是腸道微生物失調,患者腸道中細菌減少 而有很多酵母酵母菌把醣醱酵產生酒精,如果再加上肝臓處理酒精能力不足,患者食用碳水化合物就會酒醉。自釀症亦會引起小腸滲透問題,造成維他命B、鋅和鎂缺乏。

自釀症病情可透過抗真菌藥和低碳水化合物飲食來控制。預防自釀症,保持腸道微生物組健康相當重要。

 

參考資料/延伸閱讀:

<益生第一關>2018/08/17--『啤酒都可以飲得健康?』

https://hskgene.com/blogs/probiolife-first/beer

 

Google Images: 自動釀酒綜合症Auto-BrewerySyndrome

Easy Reading:

Auto-Brewery Syndrome Symptoms and Treatment - Verywell Mind

https://www.verywellmind.com/what-is-auto-brewery-syndrome-22478?print

 

Man Gets Drunk without Drinking | Discovery Life | YouTube

https://www.youtube.com/watch?v=XAsiPRypLyg

 

為什麼有的人吃點薯片都能醉? - BBC 英伦网 - BBC.com

https://www.bbc.com/ukchina/trad/vert_fut/2015/10/151005_vert_fut_the-man-who-gets-drunk-on-chips

 

學術論文:

Cordell, B. and McCarthy, J., 2013. A case study of gut fermentation syndrome (auto-brewery) with Saccharomyces cerevisiae as the causative organism. International Journal of Clinical Medicine4(07), p.309.

https://file.scirp.org/pdf/IJCM_2013070411021392.pdf

 

Painter, K. and Whitten, R.A., 2018. Auto-brewery Syndrome (Gut Fermentation). In StatPearls [Internet]. StatPearls Publishing.

https://www.ncbi.nlm.nih.gov/books/NBK513346/

 

Guo, X., Zhang, W., Huang, R., Ma, J., Liu, Z., Hu, D., Chen, J., Sun, Y. and Liu, W., 2018. Case Report The case study of one patient with gut fermentation Syndrome: case report and review of the literature. Int J ClinExp Med11(4), pp.4324-4329.

http://www.ijcem.com/files/ijcem0061289.pdf

 


2 comments

  • Greetings, Chui Hing Wa!
    Thank you for your support. Please feel free to forward our articles to your students and friends!

    海山基因 團隊
  • A very interesting and good article. As a teacher,I have forwarded to my students. They can learn how to apply textbook knowledge to explaining daily phenomenon. Thanks a lot.

    Chui Hing Wa

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