
精簡版於2021年12月31日晴報刊登
益生菌能改善腸道、調節免疫力等功能大家都知。除了這些功效外,亦有部份益生菌有其他特別效用。例如前文介紹關於腸腦軸的情緒益生菌副乾酪乳桿菌 Lpc-37 (Lactobacillus paracasei Lpc-37 ),在動物實驗中亦發現有不少與腸腦軸相關的功效。
副乾酪乳桿菌LPC-37 配合輔助減感染
副乾酪乳桿菌 Lpc-37 (Lactobacillus paracasei Lpc-37 )是從奶品中發現的益生菌,它的基因圖譜、穩定性及安全性等都已通過測試,並在歐洲EFSA及美國FDA取得安全認證。多年來Lpc-37大多作為多元益生菌組合的其中一種,配合基本的調理腸道功能,及與其他益生菌相輔相成。例如在印度的研究中,Lpc-37配合HN019作為補充劑給學齡前兒童服用九個月後,他們因感染而發燒腹瀉的發病率都有所降低。
憂鬱焦慮壓力大 益生菌舒壓降皮質醇
近年有動物實驗以每天定時束縛小鼠令其有心理壓力及焦慮,再分別以益生菌或安慰劑餵飼。在測試焦慮行為的迷宮及礦野測試中,Lpc-37組別小鼠因束縛而出現的焦慮行為明顯改善至沒有束縛小鼠的水平。而在抑鬱及認知功能測試中,Lpc-37組別都有顯著的改善。因壓力而上升的「壓力賀爾蒙」皮質醇,在Lpc-37組別中亦能回復至沒有束縛小鼠的水平。另有實驗以剝奪小鼠的睡眠時間令其認知能力下降,再以Lpc-37益生菌或安慰劑餵飼。結果發現食用Lpc-37小鼠在認知行為測試中有顯著改善至正常水平。
副乾酪乳桿菌 Lpc-37 以動物實驗為基礎,證實其調控情緒賀爾蒙、舒緩壓力及與其他益生菌相輔相成的功效。新推出的益緒寧富含170億副乾酪乳桿菌 Lpc-37及聚葡萄糖(Polydextrose)益生元,有助調節腸腦軸、改善情緒等。而有關Lpc-37更多的臨床研究,敬請留意後續《益生第一關》再一一介紹。
參考資料/延伸閱讀:
<益生第一關>2021/12/17--『益生菌調理腸道 有助治療自閉症』
https://hskgene.com/blogs/probiolife-first/probiotics_and_autism
<益生第一關>2021/12/03 --『自閉症腸道相關 微生態有助改善』
https://hskgene.com/blogs/probiolife-first/autism
<益生第一關>2021/07/30 --『腸道大腦互影響 行為健康同維持』
https://hskgene.com/blogs/probiolife-first/gut-brain-axis-behavior
<益生第一關>2017/12/08---『腸道細菌影響大腦功能。大腦與第二大腦對話』
https://hskgene.com/blogs/probiolife-first/gut-brain-axis
<益生第一關>2016/06/09---『幸福從腸道開始』
<益生第一關>2018/05/25---『健康腸道菌 舒緩「腸易激」(二)』
https://hskgene.com/blogs/probiolife-first/irritable-bowel-syndrome-2
<益生第一關>2017/04/07--『健康腸道菌紓緩「腸易激」』
https://skypost.ulifestyle.com.hk/article/1765890/%E5%81%A5%E5%BA%B7%E8%85%B8%
Easy Reading:
皮質醇過高不只老得快!失智、糖尿病7大健康風險和它有關|早安健康|2019-11-22
https://www.edh.tw/article/22925
壓力過大恐讓5種疾病跟著來! | Heho健康 |2020-06-06
https://today.line.me/tw/v2/article/nyppWo
The Gut-Brain Connection: How it Works and The Role of Nutrition| Healthline|08-20-2020
https://www.healthline.com/nutrition/gut-brain-connection#TOC_TITLE_HDR_5
Is Anxiety Making You Poop? Here’s How to Soothe Your Stomach|Healthline|03-09-2021
https://www.healthline.com/health/mental-health/is-anxiety-making-you-poop-heres-how-to-soothe
Stress, not diet, likely source of GI problems in children with autism|Healio| 07-14-2017
Dopamine and Parkinson's disease: What to know| Medical News Today| 06-01-2021
https://www.medicalnewstoday.com/articles/dopamine-parkinsons
Google images:
IBS autism IBS cortisol Parkinson's disease Dopamine
學術論文:
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Masato A, Plotegher N, Boassa D, Bubacco L. Impaired dopamine metabolism in Parkinson’s disease pathogenesis. Mol Neurodegeneration. 2019;14: 35. doi:10.1186/s13024-019-0332-6
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