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PS128: 益生菌乳酸桿菌 紓壓護腦減焦慮

益生菌乳酸桿菌  紓壓護腦減焦慮

益生菌能改善腸道、調節免疫力等功能大家都知。除了這些功效外,亦有部份益生菌有其他特別效用。例如前文介紹關於腸腦軸及能改善兒童自閉症狀的植物乳桿菌PS128 (Lactobacillus plantarum PS128 ) 在動物實驗中亦發現有不少與腸腦軸相關的功效。PS128是較新的益生菌株,十多年前由台灣團隊在客家傳統醃菜---福菜中發現。它有抗胃酸及膽鹼的特性;其安全性亦在動物及臨床實驗中證實,並獲得歐美、日本、中國等地的食用安全認證。PS128在前期動物實驗中發現其調節腦部的效用及機制,為後期的臨床研究奠定基礎。

植物乳桿菌PS128  舒緩腸道減痛感

腸道敏感是腸躁症(IBS)症狀,在自閉症患者中亦常見。有研究利用藥物(5-HTP)和物理方法,在沒有炎症的情況下誘發小鼠腸道敏感疼痛;再分別餵食兩組小鼠PS128和生理鹽水。由肌電圖及腦部有關痛覺的蛋白質顯示,服用PS128組別的小鼠的疼痛反應明顯較少、血液皮質酮(Corticosterone,小鼠的皮質醇)濃度明顯較低;神經傳導物質(Neurotransmitter)如CGRP、BDNF及NGF 等亦恢復至正常水平。可見PS128能調節神經反應及壓力賀爾蒙,而在其後的臨床測試中亦證實PS128能降低受試者唾液中的皮質醇(Cortisol)水平。

憂鬱焦慮壓力大    益生菌舒壓降皮質醇

亦有小鼠研究以母子分離模擬壓力,令剛出生小鼠出現憂鬱症狀,再分組餵食PS128和生理鹽水。結果發現服用PS128的小鼠在水中的求生時間及迷宮中央移動距離明顯較長、對喜愛糖水的興趣明顯恢復,反映其憂鬱及焦慮的症狀得以改善。服用PS128小鼠的血液皮質酮濃度明顯降低、腦部多巴胺(Dopamine)及血清素(Serotonin)水平亦有所調整。可見PS128能調控情緒賀爾蒙、舒緩壓力及改善憂鬱焦慮;亦於其後的臨床實驗中獲得證實。

腦退化神經壞死  益生菌護神經助平衡

腦部黑質(Substantia nigra)製造多巴胺的神經元退化及壞死是腦退化症的症狀之一;能導致患者產生行動控制障礙,如手顫、動作緩慢、容易失平衡等。有研究以神經毒素MPTP破壞小鼠的多巴胺神經元、模擬腦退化症狀,並分組餵食PS128或生理鹽水。結果發現服用PS128小鼠在爬竿的速度/活動力試驗及過高窄橫桿的平衡力試驗中的表現明顯較佳、腦部多巴胺神經元的數目亦明顯較多。顯示PS128能保護腦部多巴胺神經元,從而改善行動控制。其後亦有相關的腦退化症臨床實驗亦發現相似結果。

植物乳桿菌PS128以動物實驗為基礎,證實其調控情緒賀爾蒙、舒緩壓力及保護腦神經的功效。新推出的益緒寧富含300億植物乳桿菌PS128及菊苣纖維(Inulin)益生元,有助調節腸腦軸、改善情緒等。而有關PS128更多的臨床研究,敬請留意後續《益生第一關》再一一介紹。

 

參考資料/延伸閱讀:

<益生第一關>2021/12/17--『益生菌調理腸道 有助治療自閉症』

https://hskgene.com/blogs/probiolife-first/probiotics_and_autism

<益生第一關>2021/12/03 --『自閉症腸道相關 微生態有助改善』

https://hskgene.com/blogs/probiolife-first/autism

<益生第一關>2021/07/30 --『腸道大腦互影響 行為健康同維持』

https://hskgene.com/blogs/probiolife-first/gut-brain-axis-behavior

<益生第一關>2017/12/08---『腸道細菌影響大腦功能。大腦與第二大腦對話』

https://hskgene.com/blogs/probiolife-first/gut-brain-axis

<益生第一關>2016/06/09---『幸福從腸道開始』

https://skypost.ulifestyle.com.hk/article/1831979/%E5%B9%B8%E7%A6%8F%E5%BE%9E%E8%85%B8%E9%81%93%E9%96%8B%E5%A7%8B

<益生第一關>2018/05/25---『健康腸道菌 舒緩「腸易激」(二)』

https://hskgene.com/blogs/probiolife-first/irritable-bowel-syndrome-2

<益生第一關>2017/04/07--『健康腸道菌紓緩「腸易激」』

https://skypost.ulifestyle.com.hk/article/1765890/%E5%81%A5%E5%BA%B7%E8%85%B8%

 

Easy Reading:

皮質醇過高不只老得快!失智、糖尿病7大健康風險和它有關|早安健康|2019-11-22

https://www.edh.tw/article/22925

 

壓力過大恐讓5種疾病跟著來! | Heho健康 |2020-06-06

https://today.line.me/tw/v2/article/nyppWo

 

後疫情時代 平衡腸道菌就能紓壓有活力 |健康醫療網|2020-12-11

https://www.healthnews.com.tw/news/article/48382

 

精神益生菌研究 有效緩解巴金森氏症症狀|健康2.0|2019-07-05

https://health.tvbs.com.tw/medical/317180

 

客家料理常見的酸菜、福菜、梅乾菜,竟然是來自於同一種菜? |食力foodNEXT| 04-18-2019

https://www.foodnext.net/life/culture/paper/5111307418

 

The Gut-Brain Connection: How it Works and The Role of Nutrition| Healthline|08-20-2020

https://www.healthline.com/nutrition/gut-brain-connection#TOC_TITLE_HDR_5

 

Is Anxiety Making You Poop? Here’s How to Soothe Your Stomach|Healthline|03-09-2021

https://www.healthline.com/health/mental-health/is-anxiety-making-you-poop-heres-how-to-soothe

 

Stress, not diet, likely source of GI problems in children with autism|Healio| 07-14-2017

https://www.healio.com/news/gastroenterology/20170713/stress-not-diet-likely-source-of-gi-problems-in-children-with-autism

 

Dopamine and Parkinson's disease: What to know| Medical News Today| 06-01-2021

https://www.medicalnewstoday.com/articles/dopamine-parkinsons

 

Google images:

IBS autism  IBS cortisol  Parkinson's disease Dopamine

 

學術論文:

Chao S-H, Wu R-J, Watanabe K, Tsai Y-C. Diversity of lactic acid bacteria in suan-tsai and fu-tsai, traditional fermented mustard products of Taiwan. International Journal of Food Microbiology. 2009;135: 203–210. doi:10.1016/j.ijfoodmicro.2009.07.032

https://www.sciencedirect.com/science/article/pii/S0168160509003778?casa_token=0tcpmvB_wY0AAAAA:Q8xlh0skEhUEN-NIO1uFYdvdEU1kLcpxyBXrOrbe5m_OZGPh-JdNeKUYAQBib_GY_qtpoJKyRlE

Liao P-L, Wu C-C, Chen T-Y, Tsai Y-C, Peng W-S, Yang D-J, et al. Toxicity Studies of Lactobacillus plantarum PS128TM Isolated from Spontaneously Fermented Mustard Greens. Foods. 2019;8: E668. doi:10.3390/foods8120668

https://pubmed.ncbi.nlm.nih.gov/31835837/

Liu W-H, Chuang H-L, Huang Y-T, Wu C-C, Chou G-T, Wang S, et al. Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice. Behavioural Brain Research. 2016;298: 202–209. doi:10.1016/j.bbr.2015.10.046

https://www.sciencedirect.com/science/article/pii/S0166432815302588

Liu Y-W, Liu W-H, Wu C-C, Juan Y-C, Wu Y-C, Tsai H-P, et al. Psychotropic effects of Lactobacillus plantarum PS128 in early life-stressed and naïve adult mice. Brain Research. 2016;1631: 1–12. doi:10.1016/j.brainres.2015.11.018

https://www.sciencedirect.com/science/article/pii/S0006899315008628

Abdellatif B, McVeigh C, Bendriss G, Chaari A. The Promising Role of Probiotics in Managing the Altered Gut in Autism Spectrum Disorders. Int J Mol Sci. 2020;21: 4159. doi:10.3390/ijms21114159

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312735/

Mensi MM, Rogantini C, Marchesi M, Borgatti R, Chiappedi M. Lactobacillus plantarum PS128 and Other Probiotics in Children and Adolescents with Autism Spectrum Disorder: A Real-World Experience. Nutrients. 2021;13: 2036. doi:10.3390/nu13062036

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8231766/

Liu Y-W, Liong MT, Chung Y-CE, Huang H-Y, Peng W-S, Cheng Y-F, et al. Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2019;11: 820. doi:10.3390/nu11040820

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521002/

Liu Y-W, Wang Y-P, Yen H-F, Liu P-Y, Tzeng W-J, Tsai C-F, et al. Lactobacillus plantarum PS128 Ameliorated Visceral Hypersensitivity in Rats Through the Gut–Brain Axis. Probiotics & Antimicro Prot. 2020;12: 980–993. doi:10.1007/s12602-019-09595-w

https://link.springer.com/article/10.1007/s12602-019-09595-w

Wu S-I, Wu C-C, Tsai P-J, Cheng L-H, Hsu C-C, Shan I-K, et al. Psychobiotic Supplementation of PS128TM Improves Stress, Anxiety, and Insomnia in Highly Stressed Information Technology Specialists: A Pilot Study. Frontiers in Nutrition. 2021;8: 130. doi:10.3389/fnut.2021.614105

https://www.frontiersin.org/articles/10.3389/fnut.2021.614105/full

Liao J-F, Cheng Y-F, You S-T, Kuo W-C, Huang C-W, Chiou J-J, et al. Lactobacillus plantarum PS128 alleviates neurodegenerative progression in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse models of Parkinson’s disease. Brain, Behavior, and Immunity. 2020;90: 26–46. doi:10.1016/j.bbi.2020.07.036

https://www.sciencedirect.com/science/article/pii/S0889159120305924

Ryczko D, Dubuc R. Dopamine and the Brainstem Locomotor Networks: From Lamprey to Human. Frontiers in Neuroscience. 2017;11: 295. doi:10.3389/fnins.2017.0029

https://www.frontiersin.org/articles/10.3389/fnins.2017.00295/full

Masato A, Plotegher N, Boassa D, Bubacco L. Impaired dopamine metabolism in Parkinson’s disease pathogenesis. Mol Neurodegeneration. 2019;14: 35. doi:10.1186/s13024-019-0332-6

https://link.springer.com/article/10.1186/s13024-019-0332-6

Lu C-S, Chang H-C, Weng Y-H, Chen C-C, Kuo Y-S, Tsai Y-C. The Add-On Effect of Lactobacillus plantarum PS128 in Patients With Parkinson’s Disease: A Pilot Study. Frontiers in Nutrition. 2021;8: 378. doi:10.3389/fnut.2021.650053

https://www.frontiersin.org/articles/10.3389/fnut.2021.650053/full

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